Pair Name	Phorbol 12-myristate 13-acetate, Apicularen A
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	PRKCA	hsa5578
	Down-regulation	Expression	TUBA1B	hsa10376
	Down-regulation	Expression	TUBB3	hsa10381
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	These results suggest that the synergy between PMA and apicularen A is involved by PKCα activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer.